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Clin Cancer Res (2003) 9:273443

In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs

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Inject 2mg subcutaneously three times weekly (Monday/Wednesday/Friday)

Practice Bulletin, 196, 1-18